A field in continuous progress
Bioprocessing engineering has emerged as an important part of Biotechnology. It is now widely used to produce in large scale important and high-value products including, monoclonal antibodies, recombinant proteins, amino acids and vaccines.
The bioprocessing community is in need of new technology to address challenges in GMP compliant large-scale transfection in bioreactors. These manufacturing systems are important and provide a growing source of biologics, including therapeutics proteins and viruses. Our Nanocin™ technology can contribute to Bioprocessing by improving the cell delivery of nucleic acids. Within Bioprocessing, the challenge is to achieve efficient transfection with minimal toxicity and involve only reagents and processes that are clinically compatible. In particular, the need for scalable cost-effective manufacturing is a key requirement for the field. Tecrea provides a tool to ensure GMP bioprocessing that is compatible with medical applications.
From laboratory to factory to clinic
Our cell delivery products have a positive safety profile, ease of use, low toxicity and low cost of goods. In addition, Nanocin™ is highly stable with a long reagent shelf life at room temperature. Perhaps most importantly, Nanocin™ is available at GMP grade. Our scientists can help you to understand how best to use Nanocin™ in your bioprocessing applications.
On going experiments involving NanocinTM in scalable AAV production are generating very encouraging results. Specifically, the results show that transfection with NanocinTM is efficient and the low toxicity allows multiple serial transfections, which has allowed us to develop protocols that maximise AAV yield. The ability to serially transfect cells is a unique feature of Nanocin™ that will open new opportunities within Bioprocessing.
We see many opportunities to introduce Nanocin™ technology into the Bioprocessing field. If you aim to improve recombinant protein or virus production following transient transfection, please let us know. We would be please to discuss your needs and how Nanocin™ may be helpful in your processes.